How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome

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How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome

Systemic inflammation is very prevalent among critically ill patients, particularly those with extensive tissue injury. Although downstream mediators (cytokines) and effector cells (phagocytes) have been identified, proximal mediators originating from injured tissues remained elusive. Alarmins ("danger signals") released by necrotic/injured cells have been identified recently and certainly play...

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ژورنال

عنوان ژورنال: Annals of Intensive Care

سال: 2012

ISSN: 2110-5820

DOI: 10.1186/2110-5820-2-27